Krishna Shrinivas
ChemE grad student, Chakraborty lab , MIT
I am broadly interested in developing and applying ideas from theory and computation to study phenomena in biology, in close collaboration with experimentalists.
My PhD work has primarily focused on understanding the role of phase separation in gene regulation. In collaboration with the Sharp and Young labs, we have hypothesized and shown that the transcription machinery condenses into liquid-like droplets at particular genomic loci. More recently, we have begun to characterize the molecular features that lend specificity to this collective process - including aspects of the DNA (enhancer) code that drives spatio-temporally localized condensation. Along the way, I have collaborated with other lab members on problems in cell signaling, evolutionary biology , and immunology.
Apart from my technical work, I am a communication fellow at the ChemE Comm Lab where I collaborate with other fellows to develop resources aimed at promoting effective scientific communication. The open-access CommKit is one such resource.